In Chicago, a sniper kills a man under the orders of the mysterious "Mother". Even more strange, Fujiko seems to be under her spell. Lupin is on the trail of a mysterious ruby that bleeds every hundred years. As the said blood grants immortal life, he soon faces competition from other parties... Lupin has his work cut out for him as he struggles to escape Mother's crew of assassins, the sudden arrival of Zenigata, and even Fujiko.